The Iguazú National Park is a national park of Argentina, located in the Iguazú Department, in the north of the province of Misiones, Argentine Mesopotamia. It has an area of 677 km². The area of the park was inhabited 10,000 years ago by the hunter-gatherers of the Eldoradense culture. They were displaced around 1,000 CE by the Guaraní, who b…The Iguazú National Park is a national park of Argentina, located in the Iguazú Department, in the north of the province of Misiones, Argentine Mesopotamia. It has an area of 677 km². The area of the park was inhabited 10,000 years ago by the hunter-gatherers of the Eldoradense culture. They were displaced around 1,000 CE by the Guaraní, who brought new agricultural technologies, and were displaced in turn by the Spanish and Portuguese conquistadores in the 16th century, though their legacy is still alive in this area. The first European to visit the zone was Álvar Núñez Cabeza de Vaca, in 1542; Jesuit missions followed in 1609.