San Francisco 49ers quarterback Brock Purdy throws to tight end George Kittle who gains 24 yards against the Tennessee Titans.

San Francisco 49ers QB Brock Purdy's quick throw to TE George Kittle resulted in a 24-yard gain in the team's Week 15 matchup.

49ers quarterback Brock Purdy has commented on what it’s like to be without trusted wide receiver Brandon Aiyuk, one of his most lethal offensive weapons on the field.

San Francisco 49ers quarterback Brock Purdy goes airborne on a jump pass for his third touchdown toss of the game, a 1-yard score to tight end George Kittle.

Despite all of the team's injury issues, the San Francisco 49ers (9-4) find themselves just one game behind the NFC West-leading Los Angeles Rams and Seattle Seahawks. An easy win is what San Francisco needs,

George Kittle backed 49ers teammate Jauan Jennings' trash talk, stating the San Francisco receiver "toes that line perfectly" without crossing it.

Tennessee Titans defensive tackle Jeffery Simmons is willing to do whatever it takes to get his team in the win column. He's even willing to line up on offense

The 49ers are 12.5-point favorites, per the latest Titans vs. 49ers odds, and the over/under for total points scored is 44.5 at DraftKings. The 49ers are -901 money line favorites (risk $901 to win $100),