Christian McCaffrey, Kyren Williams, & Najee Harris have carried heavy workloads in their NFL careers. Injury concerns will raise caution in fantasy football.

When the 49ers offense is healthy, it's one of the best in the NFL. Unfortunately, their offense wasn't healthy last year, and it isn't healthy now.

The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

The 49ers may provide an indication of how they're feeling about their RB depth in the days ahead. If they sign another ...

The 49ers are hoping to rebound from a lost season in 2024 and Christian McCaffrey's return from injury will be a major boost ...

Mackenzie Brooks and the Inside the Lines Team break down where every NFC West team's season is most likely to end and how to ...

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

San Francisco's Christian McCaffrey revealed the unteachable traits that make 49ers QB Brock Purdy "so special." ...

Two top contenders this year face off in the preseason opener, with the San Francisco 49ers hosting the Denver Broncos. However, many fans are wondering whether stars Christian McCaffrey and Bo Nix ...

Kittle’s wife, Claire Kittle, however, still attended the game despite the absence of her better half from the matchup. The ...

There wasn’t a lot to learn from the 49ers’ 30-9 exhibition loss Saturday night to the Denver Broncos. Denver basically had ...

San Francisco 49ers coach Kyle Shanahan explained why he has confidence that fatherhood won’t change “psycho” Christian McCaffrey.