The Trump administration is warning Harvard University that it could take over its patents, worth hundreds of millions of dollars, if a review finds the university hasn’t complied with federal law, an escalation of the continuing negotiations between the White House and America’s oldest university.

In a letter sent to Harvard President Alan M. Garber on Friday, Commerce Secretary Howard Lutnick alleges the university failed to follow several regulations outlined in federal law.

After losing nearly $3 billion in research funding, Harvard University now risks losing control of its intellectual property in a latest Trump administration action.