The Aurora/Ipl1 family of protein kinases plays multiple roles in mitosis and cytokinesis. Here, we describe ZM447439, a novel selective Aurora kinase inhibitor. Cells treated with ZM447439 progress ...

When a cell starts splitting into two daughter cells, its chromosomes align. The process of chromosome alignment can be likened to a high-stakes game of tug-of-war. In a healthy cell, chromosomes line ...

The accurate segregation of chromosomes in mitosis requires the stable attachment of microtubules to kinetochores. The details of this complex and dynamic process are poorly understood. In this study, ...

A research team from the University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell ...

A research team from The University of Osaka, in collaboration with the Massachusetts Institute of Technology, has uncovered a new molecular mechanism underlying chromosome alignment during cell ...

Recently, the research team led by Wei Li and Chao Liu from Guangzhou Medical University Affiliated Women and Children's Medical Center, in collaboration with Fei Gao’s team from the Institute of ...

Even the smallest errors in this process will have dire physiological consequences. A multilayered challenge The kinetochore is the point of contact of chromosomes with the spindle, and is therefore ...

In about one out of every 800 people, two chromosomes fuse together to form an unusual bond. These are known as Robertsonian chromosomes. It's a mystery that has long stumped scientists. Now, ...

Summary of this study. Left: Normal cells. Second from left: Cells with slightly reduced CENP-E function. These cells show slightly delayed chromosome alignment but remain viable before KIF18A ...