Standard laboratory tests can fail to detect many disease-causing DNA changes. Now, a novel 3D chromosome mapping method can reliably reveal these hidden structural variants and lead to new ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published ...

The genetic heritage is not a simple, static list inside the cell nucleus. It unfolds into a dynamic architecture whose ...

A new genome-wide mapping method finally shows how thousands of genes connect to drive disease. Biomedical researchers are working intensively to identify the genes that contribute to disease, with ...

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer. DNA is well-known for its double helix shape. But the human genome ...

DNA methylation is an epigenetic modification crucial to normal development, with its dysregulation leading to various diseases including cancer. As interest in epigenomics grows, an innovative ...

Innovative study of DNA’s hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer. DNA is well-known for its double helix shape. But the human genome ...

This image depicts the detection of structural variants (SVs) at low sequencing coverage in both unique and repetitive regions by genomic proximity mapping (GPM), compared with other SV-calling ...