The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...
Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...
Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...
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