ascopubs.org

Association of matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-2 (MMP-2) expression with KRAS/BRAF mutational status and survival outcomes in metastatic ...

Inhibition of FGFR4 increases oxaliplatin and 5-fluorouracil sensitivity in Kras wild-type and mutant colorectal cancer cells. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I.
JSTOR Daily

Gliomas Induce and Exploit Microglial MT1-MMP Expression for Tumor Expansion

Diffuse infiltration of glioma cells into normal brain tissue is considered to be a main reason for the unfavorable outcomes of patients with malignant gliomas. Invasion of glioma cells into the brain ...
BMJ

Changes in mechanical loading lead to tendonspecific alterations in MMP and TIMP expression: influence of stress deprivation and intermittent cyclic hydrostatic compression on ...

Background Tendinopathy commonly occurs in tendons with large in vivo loading demands like the Achilles tendon (AT) and supraspinatus tendon (SST). In addition to differences in their local anatomic ...
JSTOR Daily

Id-1 as a Molecular Target in Therapy for Breast Cancer Cell Invasion and Metastasis

Mammary epithelial cells constitutively expressing Id-1 protein are unable to differentiate, acquire the ability to proliferate, and invade the extracellular matrix. In addition, Id-1 is aberrantly ...
Nasdaq

Bicycle Therapeutics Announces Presentation of Additional Human Radiopharmaceutical Imaging Data for MT1-MMP at the American Association for Cancer Research Annual Meeting 2025

CAMBRIDGE, England & BOSTON--(BUSINESS WIRE)-- Bicycle Therapeutics plc (NASDAQ: BCYC), a biopharmaceutical company pioneering a new and differentiated class of therapeutics based on its proprietary ...
EurekAlert!

Retromer complex: A novel regulator of melanoma metastasis

The VPS35/Retromer complex plays a crucial role in regulating MT1-MMP, an enzyme essential for cancer metastasis, by controlling both its stability and recycling. The complex binds to MT1-MMP, ...