Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that significantly impairs cognitive function and mental health, affecting ...

When neuroscientists analyzed the exact properties of nerve connections in the brain, they made a startling observation: At a key connection, or synapse, messages are sent against the usual stream of ...

BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and ...

This is a preview. Log in through your library . Abstract Hyperpolarization-activated nonselective cation channels (Ih channels) play an important role in the control of membrane excitability and ...

Physiological functioning and homeostasis of the brain rely on finely tuned synaptic transmission, which involves nanoscale alignment between presynaptic neurotransmitter-release machinery and ...

How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, ...

(1) A nerve impulse arrives. (2) This causes calcium ion channels to open, resulting in an influx of calcium ions in the terminal. (3) This causes synaptic vesicles to fuse with the terminal membrane, ...

The inherent ability of the neurons in the brain to rewire, reconnect, learn, and store new information with each new experience—called synaptic plasticity—requires the synthesis of new proteins that ...

Synaptic pruning is the process in which the brain removes neurons and synapses that it does not need. This usually takes place when a person is 2–10 years old. The brain contains millions of neurons ...