Rheumatoid arthritis (RA) is an autoimmune disease that affects millions worldwide and can have a devastating impact on patients' lives. Yet, about one in three patients respond poorly to existing ...

Understanding the interplay between T cells and B cells is pivotal to delineating both protective immunity and the pathogenesis of autoimmune diseases. Central to this dynamic are specialised CD4⁺ T ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal ...

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...

Sakaguchi's 1995 discovery of regulatory T cells revealed a complex immune tolerance system beyond central tolerance. Brunkow and Ramsdell identified the Foxp3 gene mutation in 2001, linking it to ...

Researchers discovered a way to keep T cells from wearing out during the fight against cancer, and the approach could make immune-based treatments far more powerful. They found that tumors use a ...

Dissecting racial, socioeconomic, and treatment disparities in peripheral T-cell lymphoma: A comprehensive Surveillance, Epidemiology, and End Results–based retrospective analysis.

It develops from the abnormal multiplication of T cells, or T-lymphocytes, a type of white blood cell essential for immune system function. The specific treatment course and prognosis for T-cell ...

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...