Although your article on therapeutic monoclonal antibodies was informative, 1 I would like to comment on a widespread misunderstanding of immunology by those engaged in engineering mouse-human ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 75, No. 12 (Dec., 1978), pp. 6044-6048 (5 pages) UV transcription mapping with recombinant DNA probes containing ...
The targeting of somatic hypermutation (SHM) occurs at two distinct levels. 'Global' targeting refers to the fact that rearranged immunoglobulin variable regions are the primary substrate for SHM. By ...
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