Jannik Sinner will launch his Australian Open title defence under a stubborn doping cloud but the whiff of scandal may do little to halt the Italian juggernaut.

Defending champion Jannik Sinner and 10-time Australian Open winner Novak Djokovic have landed in opposite sides of the draw for the season’s first major, ruling out a replay of last year’s semifinal encounter.

Defending champion Jannik Sinner and 10-time Australian Open winner Novak Djokovic have landed in opposite sides of the draw for the season's first major, with Carlos Alcaraz in the same quarter as Djokovic.

Jannik Sinner, Carlos Alcaraz and Novak Djokovic lead the men’s field at the 2025 Australian Open. MELBOURNE, Australia — Here are some of the top men at the Australian Open, which starts at Melbourne Park on Sunday morning local time (Saturday night EST), with money-line odds via BetMGM Sportsbook:

Seven former Australian Open champions are competing across both singles draws in 2025. That includes reigning champions Aryna Sabalenka and Jannik Sinner, though a few ex-winners will perhaps hope returning to a happy hunting ground can spark some much-needed magic.

Novak Djokovic is targeting an 11th Australian Open title and record 25th Grand Slam crown but faces an uphill battle against Jannik Sinner and Carlos Alcaraz. - Carlos Alcaraz - Still just 21, the Spaniard already owns four Grand Slam titles -- including the French Open and Wimbledon last year -- since bursting on the scene with victory at the US Open in 2022.