In this study, the fibronectin–ILT3 interaction is shown to represent a “stromal checkpoint” through which the extracellular matrix actively suppresses tumor-associated myeloid cells. Therapeutics ...

AbstractPurpose:. Posttreatment detection of ctDNA is strongly predictive of recurrence. Most minimal/molecular residual disease assays require prior tissue testing to guide ctDNA analysis, resulting ...

BBO-8520, a dual inhibitor of KRASG12C in its GTP- and GDP-bound states, has a novel mechanism of action that enables effector blockade and optimal target coverage, even in growth factor activated ...

Abstract. Purpose: The phase II MONARCH 1 study was designed to evaluate the single-agent activity and adverse event (AE) profile of abemaciclib, a selective inhibitor of CDK4 and CDK6, in women with ...

AbstractPurpose:. Patients with melanoma progressing on immune checkpoint blockade may benefit from adoptive transfer of tumor-infiltrating lymphocytes (TIL).Patients and Methods:. We investigated the ...

In 1775, English surgeon Percivall Pott discovered that exposure to soot in chimneys caused scrotal cancer in chimney sweeps, the first time an agent found in the workplace was directly connected to ...

AbstractPurpose:. Pelareorep (Pel) is a type 3 oncolytic reovirus that upregulates PD-L1 expression. We determined the objective response rate (ORR) with paclitaxel (Pac), Pac + Pel, or Pac + Pel + ...

Abstract. The integration of artificial intelligence (AI) in cancer research has significantly advanced radiology, pathology, and multimodal approaches, offering unprecedented capabilities in image ...

Abstract. Radiomics, the extraction of quantitative data from images, holds promise for noninvasively characterizing tumor phenotypes. Tools like LIFEx have improved the accessibility, transparency, ...

Homologous recombination is a high-fidelity DNA repair mechanism essential for maintaining genome stability. Impairment of this pathway, often due to BRCA1 or BRCA2 inactivation, leads to homologous ...

A new AI platform turns a general-purpose language model into an autonomous clinical agent that can analyze diagnostic data, interpret imaging and pathology, and generate treatment plans for patients ...

AbstractPurpose:. The VISION trial of tepotinib, a selective MET inhibitor, enrolled patients with non–small cell lung cancer and prospectively detected MET exon 14 (METex14) skipping in liquid ...