The critical role of polyamines in cell growth has led to the development of a number of agents that interfere with polyamine metabolism. These agents are used in cancer therapy.

The cytosolic spermidine/spermine N-acetyltransferase (SSAT) and polyamine oxidase (PAO) are jointly responsible for the mechanism of polyamine catabolism. PAO is more actively involved …

Dec 9, 2024 · In conclusion, polyamine research is a rapidly evolving field with significant implications for health and disease. This Special Issue provides comprehensive insights into …

Polyamine biosynthesis is associated with regulation of a number of metabolic functions including growth of cells in most of the living organisms. In mammals, ornithine is the precursor of …

Aug 4, 2025 · Consuming foods rich in these compounds can influence systemic polyamine levels. While polyamines are important for health, maintaining a balanced intake is also …

Dec 4, 2023 · This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health …

Polyamine synthesis occurs in the cytoplasm of cells from all tissues. Polyamines are synthesized from two amino acids: L-methionine and L-ornithine (an amino acid that is not found in …

High levels of polyamines are associated with proliferative pathologies such as cancer, whereas low polyamine levels are observed in aging, and elevated polyamine turnover enhances …

This review examines a variety of topics, such as polyamine source and metabolism, including metabolism, transport, and the potential impact of polyamines on health and disease. In …

Dietary intake can affect the levels of polyamines in the body, with long-term consumption of polyamine-rich foods shown to increase blood concentrations. Researchers are also exploring …